A REVIEW OF PENTOBARBITAL SODIUM USE

Watch Closely (one)pentobarbital will reduce the level or effect of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your lower in fentanyl plasma concentrations, lack of efficacy or, probably, development of a withdrawal